《恋爱先生》中，靳东饰演的程皓是一个高端牙医诊所的创办人，同时，他还有着另外一个身份——恋爱专家，热衷于帮别人解决各类情感问题，制定解决方案。令人啼笑皆非的是，程皓虽然“理论功底”扎实，却从未在实践中加以运用，活脱脱“情场小白”一枚。江疏影饰演的罗玥是个五星级酒店的大堂经理，旁人眼中风光无限，但实际上却饱受情伤，一度被贴上“霸道毒舌”的标签。
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该剧的开端，罗玥就把程皓送进了异国的警察局，这个火爆的开场之后，想必两人要开启“欢喜冤家”路线。有观众认为：“开篇还算是成功的，节奏紧凑，还带有一点小悬疑的开局，好玩。”“虽然可以猜到故事不打不相识的线索，但是人设讨好，故事还是挺吸引人的。”